Analog radio over fiber solutions for multi-band 5g systems

This study presents radio over fiber (RoF) solutions for the fifth-generation (5G) of wireless networks. After the state of the art and a technical background review, four main contributions are reported. The first one is proposing and investigating a RoF technique based on a dual-drive Mach-Zehnder modulator (DD-MZM) for multi-band mobile fronthauls, in which two radiofrequency (RF) signals in the predicted 5G bands individually feed an arm of the optical modulator. Experimental results demonstrate the approach enhances the RF interference mitigation and can prevail over traditional methods. The second contribution comprises the integration of a 5G transceiver, previously developed by our group, in a passive optical network (PON) using RoF technology and wavelength division multiplexing (WDM) overlay. The proposed architecture innovates by employing DD-MZM and enables to simultaneously transport baseband and 5G candidate RF signals in the same PON infrastructure. The proof-of-concept includes the transmission of a generalized frequency division multiplexing (GFDM) signal generated by the 5G transceiver in the 700 MHz band, a 26 GHz digitally modulated signal as a millimeter-waves 5G band, and a baseband signal from an gigabit PON (GPON). Experimental results demonstrate the 5G transceiver digital performance when using RoF technology for distributing the GFDM signal, as well as Gbit/s throughput at 26 GHz. The third contribution is the implementation of a flexible-waveform and multi-application fiber-wireless (FiWi) system toward 5G. Such system includes the FiWi transmission of the GFDM and filtered orthogonal frequency division multiplexing (F-OFDM) signals at 788 MHz, toward long-range cells for remote or rural mobile access, as well as the recently launched 5G NR standard in microwave and mm-waves, aiming enhanced mobile broadband indoor and outdoor applications. Digital signal processing (DSP) is used for selecting the waveform and linearizing the RoF link. Experimental results demonstrate the suitability of the proposed solution to address 5G scenarios and requirements, besides the applicability of using existent fiber-to-the-home (FTTH) networks from Internet service providers for implementing 5G systems. Finally, the fourth contribution is the implementation of a multi-band 5G NR system with photonic-assisted RF amplification (PAA). The approach takes advantage of a novel PAA technique, based on RoF technology and four-wave mixing effect, that allows straightforward integration to the transport networks. Experimental results demonstrate iv uniform and stable 15 dB wideband gain for Long Term Evolution (LTE) and three 5G signals, distributed in the frequency range from 780 MHz to 26 GHz and coexisting in the mobile fronthaul. The obtained digital performance has efficiently met the Third-Generation Partnership Project (3GPP) requirements, demonstrating the applicability of the proposed approach for using fiber-optic links to distribute and jointly amplify LTE and 5G signals in the optical domain.Agência 1Este trabalho apresenta soluções de rádio sobre fibra (RoF) para aplicações em redes sem fio de quinta geração (5G), e inclui quatro contribuições principais. A primeira delas refere-se à proposta e investigação de uma técnica de RoF baseada no modulador eletroóptico de braço duplo, dual-drive Mach-Zehnder (DD-MZM), para a transmissão simultânea de sinais de radiofrequência (RF) em bandas previstas para redes 5G. Resultados experimentais demonstram que o uso do DD-MZM favorece a ausência de interferência entre os sinais de RF transmitidos. A segunda contribuição trata da integração de um transceptor de RF, desenvolvido para aplicações 5G e apto a prover a forma de onda conhecida como generalized frequency division multiplexing (GFDM), em uma rede óptica passiva (PON) ao utilizar RoF e multiplexação por divisão de comprimento de onda (WDM). A arquitetura proposta permite transportar, na mesma infraestrutura de rede, sinais em banda base e de radiofrequência nas faixas do espectro candidatas para 5G. A prova de conceito inclui a distribuição conjunta de três tipos de sinais: um sinal GFDM na banda de 700 MHz, proveniente do transceptor desenvolvido; um sinal digital na frequência de 26 GHz, assumindo a faixa de ondas milimétricas; sinais em banda base provenientes de uma PON dedicada ao serviço de Internet. Resultados experimentais demonstram o desempenho do transceptor de RF ao utilizar a referida arquitetura para distribuir sinais GFDM, além de taxas de transmissão de dados da ordem de Gbit/s na faixa de 26 GHz. A terceira contribuição corresponde à implementação de um sistema fibra/rádio potencial para redes 5G, operando inclusive com o padrão ―5G New Radio (5G NR)‖ nas faixas de micro-ondas e ondas milimétricas. Tal sistema é capaz de prover macro células na banda de 700 MHz para aplicações de longo alcance e/ou rurais, utilizando sinais GFDM ou filtered orthogonal frequency division multiplexing (F-OFDM), assim como femto células na banda de 26 GHz, destinada a altas taxas de transmissão de dados para comunicações de curto alcance. Resultados experimentais demonstram a aplicabilidade da solução proposta para redes 5G, além da viabilidade de utilizar redes ópticas pertencentes a provedores de Internet para favorecer sistemas de nova geração. Por fim, a quarta contribuição trata da implementação de um sistema 5G NR multibanda, assistido por amplificação de RF no domínio óptico. Esse sistema faz uso de um novo método de amplificação, baseado no efeito não linear da mistura de quatro ondas, que vi permite integração direta em redes de transporte envolvendo rádio sobre fibra. Resultados experimentais demonstram ganho de RF igual a 15 dB em uma ampla faixa de frequências (700 MHz até 26 GHz), atendendo simultaneamente tecnologias de quarta e quinta geração. O desempenho digital obtido atendeu aos requisitos estabelecidos pela 3GPP (Third-Generation Partnership Project), indicando a aplicabilidade da solução em questão para distribuir e conjuntamente amplificar sinais de RF em enlaces de fibra óptica

VDES J2325−5229 a z = 2.7 gravitationally lensed quasar discovered using morphology-independent supervised machine learning

We present the discovery and preliminary characterization of a gravitationally lensed quasar with a source redshift zs = 2.74 and image separation of 2.9 arcsec lensed by a foreground zl = 0.40 elliptical galaxy. Since optical observations of gravitationally lensed quasars showthe lens system as a superposition of multiple point sources and a foreground lensing galaxy, we have developed a morphology-independent multi-wavelength approach to the photometric selection of lensed quasar candidates based on Gaussian Mixture Models (GMM) supervised machine learning. Using this technique and gi multicolour photometric observations from the Dark Energy Survey (DES), near-IR JK photometry from the VISTA Hemisphere Survey (VHS) and WISE mid-IR photometry, we have identified a candidate system with two catalogue components with iAB = 18.61 and iAB = 20.44 comprising an elliptical galaxy and two blue point sources. Spectroscopic follow-up with NTT and the use of an archival AAT spectrum show that the point sources can be identified as a lensed quasar with an emission line redshift of z = 2.739 ± 0.003 and a foreground early-type galaxy with z = 0.400 ± 0.002.We model the system as a single isothermal ellipsoid and find the Einstein radius θE ∼ 1.47 arcsec, enclosed mass Menc ∼ 4 × 1011 M and a time delay of ∼52 d. The relatively wide separation, month scale time delay duration and high redshift make this an ideal system for constraining the expansion rate beyond a redshift of 1

Redshift distributions of galaxies in the Dark Energy Survey Science Verification shear catalogue and implications for weak lensing

We present photometric redshift estimates for galaxies used in the weak lensing analysis of the Dark Energy Survey Science Verification (DES SV) data. Four model- or machine learning-based photometric redshift methods—ANNZ2, BPZ calibrated against BCC-Ufig simulations, SKYNET, and TPZ—are analyzed. For training, calibration, and testing of these methods, we construct a catalogue of spectroscopically confirmed galaxies matched against DES SV data. The performance of the methods is evaluated against the matched spectroscopic catalogue, focusing on metrics relevant for weak lensing analyses, with additional validation against COSMOS photo-z’s. From the galaxies in the DES SV shear catalogue, which have mean redshift 0.72 0.01 over the range 0.3 < z < 1.3, we construct three tomographic bins with means of z ¼ f0.45; 0.67; 1.00g. These bins each have systematic uncertainties δz ≲ 0.05 in the mean of the fiducial SKYNET photo-z nðzÞ. We propagate the errors in the redshift distributions through to their impact on cosmological parameters estimated with cosmic shear, and find that they cause shifts in the value of σ8 of approximately 3%. This shift is within the one sigma statistical errors on σ8 for the DES SV shear catalogue. We further study the potential impact of systematic differences on the critical surface density, Σcrit, finding levels of bias safely less than the statistical power of DES SV data. We recommend a final Gaussian prior for the photo-z bias in the mean of nðzÞ of width 0.05 for each of the three tomographic bins, and show that this is a sufficient bias model for the corresponding cosmology analysis

The Dark Energy Survey : more than dark energy – an overview

This overview paper describes the legacy prospect and discovery potential of the Dark Energy Survey (DES) beyond cosmological studies, illustrating it with examples from the DES early data. DES is using a wide-field camera (DECam) on the 4 m Blanco Telescope in Chile to image 5000 sq deg of the sky in five filters (grizY). By its completion, the survey is expected to have generated a catalogue of 300 million galaxies with photometric redshifts and 100 million stars. In addition, a time-domain survey search over 27 sq deg is expected to yield a sample of thousands of Type Ia supernovae and other transients. The main goals of DES are to characterize dark energy and dark matter, and to test alternative models of gravity; these goals will be pursued by studying large-scale structure, cluster counts, weak gravitational lensing and Type Ia supernovae. However, DES also provides a rich data set which allows us to study many other aspects of astrophysics. In this paper, we focus on additional science with DES, emphasizing areas where the survey makes a difference with respect to other current surveys. The paper illustrates, using early data (from ‘Science Verification’, and from the first, second and third seasons of observations), what DES can tell us about the Solar system, the Milky Way, galaxy evolution, quasars and other topics. In addition, we show that if the cosmological model is assumed to be +cold dark matter, then important astrophysics can be deduced from the primary DES probes. Highlights from DES early data include the discovery of 34 trans-Neptunian objects, 17 dwarf satellites of the Milky Way, one published z > 6 quasar (and more confirmed) and two published superluminous supernovae (and more confirmed)

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure &lt;= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Integrating Optical and Wireless Techniques towards Novel Fronthaul and Access Architectures in a 5G NR Framework

The fifth-generation of mobile network (5G) and beyond requires a radio access network (RAN) update in order to cope with the incoming increase of wireless data traffic and new applications. In this context, we propose an efficient optical-wireless architecture applied to the non-standalone (NSA) 5G new radio (NR) framework. Several distinct electrical- and optical-based fronthaul configurations combining free-space optical (FSO), wireless links, and radio over fiber (RoF) techniques were implemented and properly analyzed for selection according to network operator deployment requirements. In addition, visible light communication (VLC) was investigated as a future access network technology when immunity to electromagnetic interference is paramount. Experimental results demonstrated fourth-generation of mobile network (4G) and 5G coexistence at Gbit/s throughput and error vector magnitude (EVM) in accordance with 5G NR Release 15

Photometric redshifts and clustering of emission line galaxies selected jointly by DES and eBOSS

We present the results of the first observations of the emission line galaxies (ELG) of the extended Baryon Oscillation Spectroscopic Survey. From the total 9000 targets, 4600 have been selected from the Dark Energy Survey (DES). In this subsample, the total success rate for redshifts between 0.6 and 1.2 is 71 and 68 per cent for a bright and a faint samples, respectively, including redshifts measured from a single strong emission line. The mean redshift is 0.80 for the bright and 0.87 for the faint sample, while the percentage of unknown redshifts is 15 and 13 per cent, respectively. In both cases, the star contamination is lower than 2 per cent. We evaluate how well the ELG redshifts are measured using the target selection photometry and validating with the spectroscopic redshifts measured by eBOSS. We explore different techniques to reduce the photometric redshift outliers fraction with a comparison between the template fitting, the neural networks and the random forest methods. Finally, we study the clustering properties of the DES SVA1 ELG samples. We select only the most secure spectroscopic redshift in the redshift range 0.6 < z < 1.2, leading to a mean redshift for the bright and faint sample of 0.85 and 0.90, respectively. We measure the projected angular correlation function and obtain a galaxy bias averaging on scales from 1 to 10 Mpc h−1 of 1.58 ± 0.10 for the bright sample and 1.65 ± 0.12 for the faint sample. These values are representative of a galaxy population with MB − log(h) < −20.5, in agreement with what we measure by fitting galaxy templates to the photometric data